red clover cancer
ALSO KNOWN AS: Cow clover, wild clover, purple clover, beebread, cow grass, meadow clover, purple clover. © 2020 MJH Life Sciences™ and Cancer Network. Nourishing food herbs like Red Clover have been used for thousands of years with no indication the plant contributed to estrogen dominant conditions or estrogen-sensitive cancers. The isoflavone Biochanin A inhibited activity and gene expression of aromatase, an enzyme that catalyzes the conversion of androgen to estrogen (2). Wang Y, Man Gho W, Chan FL, et al. Comme vous le savez probablement, ces thérapies médicamenteuses font l'objet de discussions multiples aujourd'hui, car elles sont associées à une augmentation du risque de cancer du sein. Clinical data show that supplementation with red clover isoflavones improves menopausal symptoms compared with placebo (7) (8), but systematic reviews are mixed (9) (24) (10).  However, the red clover isoflavone biochanin A was shown to inhibit aromatase activity and expression, thereby conferring a protective effect. Cochrane Database Syst Rev. Studies suggest it is not effective in treating hot flashes. Well, this can be dangerous, both for your breast and your liver! Red clover has long been used as a “blood purifier,” specifically for the potential treatment of cancer. Red clover is used to treat cancer as well as respiratory problems such as asthma, whooping cough and bronchitis. Le Bail JC, Champavier Y, Chulia AJ, Habrioux G. Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. Isoflavones have generated considerable interest in the last decade because of their possible cancer-preventive, cardioprotective. Red clover (Trifolium pratense) is a medicinal herb containing flavonoids, coumarins, coumestans, and isoflavones. Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage through inhibition of microglia activation and proinflammatory factors generation. 4. Formononetin induces apoptosis of human osteosarcoma cell line U2OS by regulating the expression of Bcl-2, Bax and MiR-375 in vitro and in vivo. The British Journal of Nutrition discovered that red clover … Her symptoms resolved after discontinuation of the supplement.. The flower is a mainstay ingredient in traditional herbal formulas, including Essiac Tea, Jason Winters Tea, and the Hoxsey Therapy. An isoflavone extract is widely promoted as a dietary supplement to relieve menopausal symptoms. Donate today. Data from clinical trials suggest that supplementation with red clover isoflavones helps relieve menopausal symptoms. -Barrie Cassileth, PhD. Red Clover tea, made from the red blossoms, was an old remedy for winter colds. Red clover is a perennial herb traditionally used to treat skin disorders such as psoriasis and eczema, whooping cough, and mastitis. Use of this Web site does not create an expressed or implied physician-patient relationship. Int J Radiat Oncol Biol Phys. Red Clover roots have also been used to treat diphtheria. Red Clover for Bigger Breast – Side Effects. Potential uses: Red clover is used to treat menopausal symptoms and breast pain. Phytoestrogens for vasomotor menopausal symptoms. Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. Dried red clover flowers have been used in traditional medicine to treat a wide variety of ailments, including jaundice, cancer, breast tissue infections, joint disorders, and respiratory conditions (e.g, whooping cough, bronchial asthma), and as a sedative. Clinical relevance has yet to be determined.Methotrexate: Red clover was reported to cause toxicity, resulting in severe vomiting and epigastric pain, when used along with methotrexate injections (19). It also stopped the growth of normal prostate cells and increased prostate cancer cell resistance to high-dose radiation. Red clover, although it does not cause cancer, is not to be played with! The treatment of cancer with Red Clover has a great many advocates and has been with us for a long time. An isoflavone-enriched fraction showed neuroprotective activity in human cortical neurons as well, possibly due to antioxidant and estrogenic effects (4). Topical use of red clover includes for cancer, skin sores, burns, sore eyes, and chronic skin diseases including eczema. Neurocrit Care. Anticoagulants / Antiplatelets: Preclinical studies suggest red clover may increase their effects (20). The folk healers of Russia used Red clover to treat asthma. Red Clover is not suitable for patients with hormone diseases such as breast, uterine, ovarian cancer or endometriosis. It turns out that the isoflavones in red clover may possess antitumor activity in the test tube. More studies are needed. Lukaczer D, Darland G, Tripp M, et al. It is unclear whether red clover is safe for consumption by women with a history of estrogen-receptor (ER) positive cancer. The herb has tumor-inhibiting properties and strengthens lymphatic functions (crucial in cleansing cell tissues). Cow clover, wild clover, purple clover, beebread, cow grass, meadow clover, purple clover. 1. Subdural hematoma: In a 65-year-old woman with no other risk factors for bleeding except long-term use of red clover supplements for postmenopausal symptoms. Coon JT, Pittler MH, Ernst E. Trifolium pratense isoflavones in the treatment of menopausal hot flushes: a systematic review and meta-analysis. 10. In vivo prediction of CYP-mediated metabolic interaction potential of formononetin and biochanin A using in vitro human and rat CYP450 inhibition data. Case reports Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Red Clover Uses. Keep red clover leaf extract out of the reach of children and away from pets. Red clover (Trifolium pratense) is a medicinal herb containing flavonoids, coumarins, coumestans, and isoflavones.Red clover has been claimed to be effective for treating hormonally driven cancers and for reducing hot flashes in women who experience premature menopause as part of their cancer treatment. Red clover is used to treat cancer as well as respiratory problems such as asthma, whooping cough and bronchitis. Red clover contains substances called isoflavones. Red clover does not significantly reduce total or LDL cholesterol, or increase HDL in women 49-65. Preclinical studies suggest red clover extract may act as an estrogen agonist and stimulate proliferation of ER-positive breast cancer cells (1). Red Clover herb is a simple to find herb with many uses. Whilst there have been some very preliminary scientific studies to support the anti-cancer properties of Red Clover the evidence throughout the ages, like virtually all of our herbal lore, has been gathered through experience and observation. Red clover has been used for hundreds of years as a natural herbal remedy to treat many different diseases, including joint problems, respiratory illnesses, muscular aches and pains (particularly mastitis), inflammation of the skin and other soft tissue, and many types of cancer. CONTRAINDICATIONS AND ADVERSE REACTIONS: Patients with hormone-sensitive cancers should avoid red clover because of its estrogenic activity. And they are going to start consuming it in very large amounts! Therefore, patients with estrogen receptor-positive cancers or undergoing radiotherapy for prostate cancer should avoid using red clover. 2005;21:257-64. The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. The Early Christians looked at the symbolism of plants and associated the three lobed leaves with the Trinity. 2012 Jan;28(1):29-33. doi: 10.3109/09513590.2011.579660. Its active ingredients include phytoestrogens. Hidalgo LA, Chedraui PA, Morocho N, et al. Patients should consult with their physicians before taking red clover supplements. They are found in legumes, such as soy and red clover (RC) and mimic the actions of estrogen through ER binding and activation of ER-dependent gene transcription . In addition, it protected dopaminergic neurons against lipopolysaccharide-induced damage by inhibiting microglial activation and proinflammatory factors (3). Red clover does not seem to reduce menopausal symptoms. It is unclear whether red clover is safe for consumption by women with a history of estrogen-receptor (ER) positive cancer. 2007(4):CD001395. Cattle and other animals graze on red clover. An increase in density is associated with a higher risk of breast cancer, inferring that … Also, red clover may increase the effects of anticoagulants and antiplatelet drugs. 7. Red clover supplements are available as capsules, tablets, tinctures, and teas. Russian folk healers and traditional Chinese physicians have long used Red Clover for asthma, bronchitis and to clear the lungs. It also stopped the growth of normal prostate cells and increased prostate cancer cell resistance to high-dose radiation. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. The red clover plant actually belongs to the legume plant family (just like peanuts and beans), which is why animals often graze on it in the wild. Red clover has also been contraindicated with heparin, ticlopidine, and warfarin, based on its coumadin content. Red clover traditional medicine uses. Usual dose: To relieve hot flashes, an extract of 40 to 160 milligrams per day has been used. Red clover may also block enzymes thought to contribute to prostate cancer in men. Formononetin, an isoflavone, induced apoptosis in human breast cancer cells by activating the Ras-p38 mitogen-activated protein kinase in ER-positive breast cancer cells (23). Clinical Consult: Assessing the Impact of Tailor X. Red Clover is one of the ingredients s of the ‘controversial Hoxsey cancer treatment,’ developed by Harry Hoxsey in the 1920’s. Overuse of isoflavone supplements can increase the risk of hormone-sensitive cancer. There is no evidence that red clover can help treat cancer. Users of this Web site should not rely on information provided on this Web site for their own health problems. Red clover (Trifolium pratense L.) is a plant in the Fabaceae botanical family. Red Clover’s Anti-Cancer Effects Red clover contains a weak phytoestrogen called formononetin. Your generosity makes this possible. Red clover is used in Turkish folk medicine as expectorant, antiseptic, analgesic properties and as a treatment for rheumatic aches. The formula was developed after his grandfather observed what sick horses grazed on to restore their health. Gynecol Endocrinol. Red clover has been claimed to be effective for treating hormonally driven cancers and for reducing hot flashes in women who experience premature menopause as part of their cancer treatment. It has also been used medicinally to treat several conditions including cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. In reality, Red Clover is the best-known anti-cancer herb in Western Herbalism.  In other studies, red clover isoflavones reduced bone loss and improved arterial compliance (the latter is an index of the elasticity of large arteries, an important cardiovascular risk factor). Studies of individual components of red clover show some cancer fighting action in vitro . C'est pour cette raison que de […] Here are a few of the most common uses. In alternative medicine, red clover is said to help with the following conditions. [1,2,3] However, conclusions from systematic reviews have been conflicting: one suggested marginal benefit, whereas another found no evidence of effectiveness. In a murine model, red clover isoflavones reduced skin aging induced by estrogen deprivation following ovariectomy (5). Please keep in mind that clinical studies have shown that some phytoestrogens have anti-cancer properties. Subarachnoid hemorrhage was reported in a 53-year-old woman following use of an herbal supplement that contained red clover, dong quai, and Siberian ginseng, which she took for hot flashes associated with perimenopause. In another, the patient required intensive medical interventions to resolve issues. This Web site — Information About Herbs, Botanicals and Other Products — is for general health information only. 1999;84:895-98. Hasan Y, Schoenherr D, Martinez AA, et al. In red clover blossoms, the compounds biochanin-A, caffeic acid, chlorogenic acid, coumarin, formononetin, genistein and isorhamnetin all demonstrate some anti-cancer … Recent findings from a preclinical study suggest that red clover may increase resistance of prostate cancer cells to high-dose radiation while inhibiting the growth of normal prostate cells. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Patients with hormone-sensitive cancers should avoid red clover because it has estrogenic activity, Red clover may increase effects of anticoagulants and antiplatelet drugs, Red clover causes toxic effects when used with methotrexate, © 2020 Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Integrative Medicine at Home Membership Program. 2007;7:76-80. Regardless of the myths and folktales surrounding red clover, one thing has been proven through time - the herb makes a powerful addition to your natural medicine arsenal. Red clover is a wild plant belonging to the legume family. Red clover extract can stimulate the production of estrogen receptor-positive breast cancer cells in lab experiments. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. Of concern are findings that red clover inhibits the growth of normal prostate cells and increases resistance of prostate cancer cells to high-dose radiation in vitro (15). Red clover is also a source of many valuable nutrients including calcium, chromium, magnesium, niacin, phosphorus, potassium, thiamine, and vitamin C. General information: If you have any questions about red clover leaf extract, please talk with your doctor, pharmacist, or other health care provider. Overuse of isoflavone supplements can increase the risk of hormone-sensitive cancer. Clinical relevance has yet to be determined.Cytochrome P450 enzymes: Preclinical studies suggest red clover can inhibit CYP 1A2, 2C8, 2C9, 2C19, 2D6, and 3A4, and may interact with substances metabolized by these enzymes (17) (28). To prevent pregnancy, be sure to use an additional form of birth control while using red clover leaf extract. As I indicated above, this is not likely to produce sufficient results. Red clover may help reduce menopausal symptoms, but additional study is needed. The isoflavones present in red clover have estrogen-like effects and have been the subject of intense research over the last decade. Acute-on-chronic subdural hematoma in a patient taking Red Clover herbal supplement: A case report. Avoid large amounts and use with caution. All rights reserved. The treatment of cancer with Red Clover has a great many advocates and has been with us for a long time. Red clover contains substances called isoflavones. Red Clover herb is a simple to find herb with many uses. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Historically, red clover was used for asthma, whooping cough, cancer, and gout. The herb has tumor-inhibiting properties and strengthens lymphatic functions (crucial in cleansing cell tissues). Cuts down on the risk of breast cancer. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models View ORCID Profile Aurelie de Rus Jacquet , Abeje Ambaw , View ORCID Profile Mitali A Tambe , Michael Timmers , Sin Ying Ma , Qing-Li Wu , James E Simon , George P McCabe , Mary Ann Lila , Riyi Shi , View ORCID Profile Jean-Christophe Rochet SUMMARY: Red clover, a perennial herb that is prevalent in Asia, Europe, and North America, has traditionally been used to treat skin disorders such as psoriasis and eczema, whooping cough, and mastitis. It contains compounds known as isoflavones that act as phytoestrogens. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. Red clover is used to purify blood by enhancing urine, production of mucous, enhancing circulation and stimulating bile secretion. Studies on whether red clover may help reduce menopausal symptoms are mixed, and additional study is needed to confirm positive effects and safety with long-term use. Two: This is often used for children that have a persistent, bad cough. Red clover is one of the richest sources of isoflavones. Compounds in red clover include phytoestrogenic isoflavones such as genistein, diadzen, formononetin and biochanin A. The loss of elasticity can contribute to increased blood pressure, causing the heart to work harder. Red Clover (Trifolium pratense) Red Clover (Trifolium pratense). Until definitive data are available, patients should avoid use of red clover during radiotherapy for prostate cancer. Red clover: Red clover has been hailed as "the" herb for cancer by many herbalists. MSK is revolutionizing the way cancer is understood, diagnosed, and treated. It also inhibited proliferation of human osteosarcoma U2SO cells by decreasing expression of miR-375 and Bcl-2, an apoptotic repressor, while increasing Bax, a pro-apoptotic protein (27). 2005;11:60-65. Although red clover isoflavones show hormonal activity in laboratory experiments, their effects in the human body are less clear. Data on red clover’s potential for reducing the symptoms of menopause and for decreasing the risk of breast cancer are inconclusive. Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: a pilot trial. Three: Blood flow seems to be enhanced by this herb since it can help prevent blood clots and thins the blood. Red clover is an herbal supplement used orally for conditions such as menopausal symptoms and hot flashes, mastalgia, premenstrual syndrome, cancer prevention, indigestion, hypercholesterolemia, whooping cough, asthma, bronchitis, and sexually transmitted diseases.. Topical use of red clover includes for cancer, skin sores, burns, sore eyes, and chronic skin diseases including eczema. These include biochanin, daidzein, formononetin, and genistein. Red clover extracts (RCE) are rich in isoflavones, particularly genistein and daidzein and they have been proved to be effective in reducing vasomotor symptoms in a number of studies. 2000;66:1281-91. Red clover has similar effects to estrogen and could complicate these conditions and interfere with treatment. I say this because a lot of women are simply going to think that red clover is completely safe. Maturitas. Red clover is a perennial herb traditionally used to treat skin conditions such as... ALSO KNOWN AS: . Altern Ther Health Med. Red clover is a wild plant belonging to the legume family. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. However, compared to estrogen, which has relative high binding affinity for the ER-α and ER-β, isoflavones demonstrate up to ~1600 times lower affinity for ER-α meaning they should not increase the risk of cancer. Epub 2011 May 26. It is not recommended for women with estrogen-receptor-positive breast cancer. Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. Subarachnoid hemorrhage: In a 53-year-old woman following use of an herbal supplement containing red clover, dong quai, and Siberian ginseng for perimenopausal hot flashes. 2008;99:303-10. However, it is not known if red clover can protect against the development of heart disease, and this will also require more clinical trials. Red clover is a perennial herb traditionally used to treat skin conditions such as eczema and psoriasis, whooping cough, and respiratory problems. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. 2. The flower is also used for inflammatory conditions associated with arthritis and gout. Red Clover Benefits: as a Phytoestrogen. It has also been used medicinally to treat several conditions including cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. Another recent study found that red clover inhibited the growth of normal prostate cells and increased the resistance of prostate cancer cells to high-dose radiation in vitro. Today, extracts from red clover are most often promoted for menopause symptoms, high cholesterol levels, or osteoporosis. Red clover may interfere with hormonal therapy drugs. While historically the RC plant has been taken in the form of tea and tinctures, today it’s often used to make extracts, such as the products … 3. van de Weijer PH, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Two: This is often used for children that have a persistent, bad cough. Statements made about products have not been evaluated by the Food and Drug Administration. Cancer: Red clover has been studied for its ability to inhibit the growth of new blood vessels to tumours. Atkinson C, Compston JE, Day NE, et al. Nestel PJ, Pomeroy S, Kay S, et al. Life Sci. 8. The relation between red clover and cancer is not been fully discovered yet. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. After postoperative re-hemorrhage, an intraoperative thromboelastogram confirmed that antiplatelet effects were more likely than coumarin toxicity. 2010;76:896-904. One study in menopausal women suggests that red clover extract can improve elasticity of major arteries. Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate. Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. Here are a few of the most common uses. Overview. 5. Red clover contains compounds known as isoflavones that act as phytoestrogens. Phytoestrogens for vasomotor menopausal symptoms. Due to their partial selectivity of action on estrogen receptors (ERs) these compounds have been claimed to … Historically, red clover was used for asthma, whooping cough, cancer, and gout. Isoflavones are effective in treating several conditions such as hot flashes, cardivascular health and osteporosis. Overview. In addition, here is an article from the Mayo Clinic mentioning how isoflavones in food such as soy are not sufficient to cause breast cancer, and in fact a lifelong diet including such foods actually reduces breast cancer: Read the article from the Mayo Clinic (Red clover is an herb, which is considered a food). Genistein, an active component of red clover is believed to be one of 4 herbs responsible for … However, unless red clover herb is fermented, it is unexpected to have any anticoagulant effects. J Clin Endocrinol Metab. Symptoms resolved after supplement discontinuation (16). Red clover isoflavones are safe and well tolerated in women with a family history of breast cancer. It has also been used medicinally to treat several conditions including cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. If your symptoms do not improve or if they become worse, contact your doctor or pharmacist as soon as possible. However, unless red clover herb is fermented, it is unexpected to have any anticoagulant effects. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Red clover is a favorite herb for women experiencing hot flashes and other hormonal changes throughout menopause, including vaginal dryness and osteoporosis. Also known as: Daidzein, genistein, isoflavone, phytoestrogen, purple clover, trefoil, trifolium, beebread, clovone. Br J Nutr. Si vous êtes en période de ménopause, vous avez peut-être envisagé les thérapies hormonales afin de réduire les symptômes les plus gênants. Red clover extract can stimulate the production of estrogen receptor-positive breast cancer cells in lab experiments. Supplements containing red clover isoflavones do not adversely affect breast density, skeletal strength or cardiovascular status. Cattle and other animals graze on red clover. Dietary isoflavone intake also improved arterial compliance, an index of large artery elasticity which is an important cardiovascular risk factor (12). The June 2004 edition of Breast Cancer Research states that “red clover does not cause any estrogenic increase in breast density, while human and synthetic estrogen does. The controversy concerning the use of red clover for the treatment of cancer is twofold. In a trial involving osteopenic postmenopausal women, a red clover extract rich in isoflavones, aglycones, and probiotics attenuated bone mineral density loss caused by estrogen deficiency and improved bone turnover (26). Red clover contains the anticoagulant and blood-thinning compound coumarin. Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. Three: Blood flow seems to be enhanced by this herb since it can help prevent blood clots and thins the blood. Prostate-specific natural health products (dietary supplements) radiosensitize normal prostate cells. Prostate-specific natural health products (dietary supplements) radiosensitize normal prostate cells. The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Secondly, some of the types of cancer for which red clover has been traditionally used include cancers of the breast, uterus, ovaries, and prostate, for which estrogenic activity is considered to be contraindicated. Potential interactions between alternative therapies and warfarin. In postmenopausal women, endometrial status was not adversely affected. Red clover contains isoflavone compounds similar to those found in soy. An increase in density is associated with a higher risk of breast cancer, inferring that taking red clover could prove to … Firstly, some proponents of its use have suggested that it is effective enough to be used on its own. Today, extracts from red clover are most often promoted for menopause symptoms, high cholesterol levels, or osteoporosis. © 2020 MJH Life Sciences and Cancer Network. Red clover is a reserve of protein and unique phytochemicals. Do not take red clover if on a blood thinner, or when using melilot an herb that enhances bleeding. Among classic herbalists, red clover is known as one of the world’s oldest and most common natural herbal supports for the treatment for all varieties of cancer — anywhere in the body. Am J Clin Nutr. Cattle and other animals graze on red clover. Red clover contains substances called isoflavones. In postmenopausal women, supplementation alleviated vasomotor and menopausal symptoms (18) (25). Red Clover Kills Prostate Cancer Cells By Michael A. Smith, MD More than 238,000 men will be diagnosed with prostate cancer in the United States, and nearly 30,000 will die from it. Patients taking hormonal contraceptives should not use clover, as this may reduce the effect of contraception. 2004;79:326-33. In red clover blossoms, the compounds biochanin-A, caffeic acid, chlorogenic acid, coumarin, formononetin, genistein and isorhamnetin all demonstrate some anti-cancer … Friedman JA, Taylor SA, McDermott W, Alikhani P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Do not share it with other people. Red clover leaf extract may decrease the effectiveness of your birth control pill. German Mennonites took the plant over with them to America and it is still used to help treat whooping cough, croup and to give support in some cancers. Now before going any further, I know that some of you object to using a phytoestrogen for prostate cancer. Isoflavone-enriched extracts have shown neuroprotective effects in human cortical neurons (3) (4) and reduced skin aging in mice by increasing collagen (5). Red clover contains a mild sedative property, which complements its antispasmodic effects for cough. It is important that we be clear on the research. No one with a hormone sensitive condition such as uterine cancer, breast cancer, ovarian cancer, uterine fibroids, or endometriosis, should use red clover.
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